BZYET-141 IMMUNOLOGY in English Solved Assignment 2022-2023

BZYET-141 IMMUNOLOGY in English Solved Assignment 2022-2023

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ASSIGNMENT
IMMUNOLOGY
Course Code: BZYET-141
Assignment Code: BZYET-141/TMA/2023
Maximum Marks: 100

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Note: Attempt all questions. The marks for each question are indicated against it.
Part-A Maximum Marks: 50
1. i) Define the following terms:
a) Tolerance
b) Autoimmunity
c) Phagocytic barriers of innate immunity
d) Inflammation
ii) Give an example of each of the following in the space provided:
Column I Column II
Bacterial disease that can be prevented
due to high body temperature
Protozoan disease
Autoimmune disorder
Cytokine
(8)
(2)
2. Write a comparative note on the role of Thymus and Bone marrow with respect
to immune response.
(10)
3. i) How does the protein structure influence the capacity of antigens to form
antibodies?
ii) Write down the differences between alloantigen and autoantigen.
(5)
(5)
4. Fill in the blanks:
i) The isotypes have similar ………………… regions of …………………
and ………………… chains but different ………………… regions of
………………… chains.
ii) The allotypes may have different amino acids in CDR regions of the
………………… chain or the ………………… chain.
iii) The idiotype provides ………………… antibodies to interact with
different ………………… in one’s own body.
iv) The fetus acquires immunity from the mother as ………………… can
cross ………………… .
(10)
5. i) Explain, Antigen processing and Antigen presentation?
ii) What are the differences between class I and class II MHC molecules?
(5)
(5)
4
Part-B Maximum Marks: 50
6. i) What is BCR? What are its functions? Which 2 Igs make up the BCRs?
ii) Describe the major events of the B-Cell maturation briefly.
(5)
(5)
7. i) Choose whether following sentence are true (T) or False (F):
a) T helper cells possess CD8+
surface markers.
b) Cytotoxic T -cells kills the antigen infected cells.
c) MHC molecule requires to present antigen peptide on the surface
of APCs.
d) CD8+ marker recognizes MHC II complex.
e) CD4+ marker recognizes MHC I complex.
f) All nucleated cells possess MHC I molecule.
ii) Define the CD and MHC molecules.
iii) Which type of antigen-presenting molecule is found only on
macrophages, dendritic cells, and B cells?
iv) Which type of antigen-presenting molecule is found on all nucleated
cells?
(6)
(2)
(1)
(1)
8. i) Match the following with the correct option of Column I with Column
II.
Column I Column II
a) Allergy i Paul Ehrlich
b) Autoimmunity ii Type-IV hypersensitivity
c) Cell-mediated
hypersensitivity
iii Type-II hypersensitivity
d) Antibody-mediated
hypersensitivity
iv Type-III hypersensitivity
e) Arthus reaction v Clemens von Pirquet
(5)
ii) State whether the following statement are ‘True’ or ‘False’:
a) The removal of self-reactive cells within our body immune system
is Tolerance.
b) The deposition of antigen-antibody complexes in tissues or blood
vessels causes the activation of complement system along with
recruitment of neutrophils.
c) Type-I hypersensitivity is accompanied by clinical symptoms like:
anaphylaxis, angioedema, bronchospasm, hypotension etc.
d) Myasthenia Gravis is a condition of muscular dysfunction arising
from acetylcholine inadequacy not auto-immunity.
e) Type-IV hypersensitivity is clinically associated with hemolytic
anemia, thrombocytopenia, neutropenia.
(5)
5
9. i) What is immunosuppressive therapy. Explain the two major types of the
same.
ii) Define the immunological tolerance highlighting the central and
peripheral tolerance.
(5)
(5)
10. i) Explain DNA vaccine.
ii) Based on formulation how many types of vaccines are there and give the
example of major preventable diseases of each?

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